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Gemcitabine (pronunciation: jem-SITE-a-been) is a nucleoside analog in use accustomed to as chemotherapy. It is marketed as Gemzar near Eli Lilly and Company. Pharmacology Chemically gemcitabine is a nucleoside analog in which the hydrogen atoms on the 2' carbon of deoxycytidine are replaced byfluorine atoms. As with fluorouracil and other analogues of pyrimidines, the triphosphate analogue of gemcitabine replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The make arrests tumor growth, as one anybody additional nucleoside can be betrothed to the "faulty" nucleoside, resulting in apoptosis. Another end of gemcitabine is the enzyme ribonucleotide reductase (RNR). The diphosphate analogue binds to RNR active plat and inactivates the enzyme irreversibly. Years RNR is reserved, the chamber cannot compose the deoxyribonucleotides required representing DNA replication and restore, and cubicle apoptosis is induced.[1 - From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
